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During treatment with Differin 0.1% dryness, erythema, burning or pruritus can occur. These side effects differ in frequency depending on the formulation used of Differin 0.1% (cream vs. gel). During treatment with Differin Gel 0.3% signs of cutaneous irritation like redness, scaling, dryness and/or stinging/burning may occur, but should be mild or moderate, occur early in treatment and decrease thereafter. Other side effects that may occur from using Differin Gel 0.3% include skin discomfort, pruritus and sunburn.

Concomitant use of potentially irritating products or overexposure to sunlight or sunlamps, extreme wind or cold, may increase the potential for irritation from both product concentrations. Use of sunscreen and protective clothing is recommended.