What is Differin®? How does Differin&#174 work? How do I use Differin®?

How does Differin® work?

When a Differin® product is absorbed into your skin, it begins to normalize the skin cells that clog pores. The result? The Differin® product gets deep into pores to help clear the acne you have and help keep new acne from starting.

Fight Back
The goal of acne therapy is to help get rid of blemishes. The Differin® product helps clear the acne you have and prevent pores from becoming clogged in the first place. Topical retinoids, like any Differin® product, are the only class of drugs proven to treat those blemishes that are present and prevent the formation of new ones.

What to Expect
If your doctor has prescribed a Differin® product, here's what to expect during your treatment.

Early Days of Treatment
We'll give it to you straight: Your acne might seem to get worse before it gets better. Don't despair! It means the medication is working—acting on pimples that began forming before you started treatment.

Possible Side Effects
Itching, dryness, redness, burning or peeling

What You Can Do
Limit sun exposure, including sunlamps. Also make sure to use sunscreen and protect your skin from extreme wind or cold. If you're still experiencing issues, discuss it with your doctor.

The million-dollar question: How long before acne clears up? It could take 8-12 weeks for noticeable results. Don't get discouraged and stop treatment early – like most things worth waiting for, a clearer complexion takes a little patience.

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Important Safety Information

Differin® Lotion 0.1% and Differin® Gel 0.3% are indicated for the topical treatment of acne vulgaris in patients 12 years and older. Cutaneous irritation (erythema, scaling, dryness and/or stinging/burning) has been reported in clinical studies of these products. The majority of cases were mild to moderate in severity, occurred early in treatment and decreased thereafter. Other side effects that may occur from using Differin Lotion 0.1% and Differin Gel 0.3% include dry skin, skin discomfort, pruritus, desquamation and sunburn.

Concomitant use of potentially irritating products or overexposure to sunlight or sunlamps, extreme wind or cold, may increase the potential for irritation. Use of sunscreen and protective clothing over treated areas are recommended when exposure cannot be avoided. Do not use Differin Lotion 0.1% and Differin Gel 0.3% if you are allergic to adapalene or any of the other ingredients in the product. Talk to your doctor to learn more about Differin Lotion 0.1% and Differin Gel 0.3%.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

*Insured patients could pay no more than $35 for their Differin® (adapalene) Gel, 0.3% or Differin® (adapalene) Lotion Pump, 0.1% prescription (for one tube or pump, after primary insurance and the Differin Savings at Work Card and includes a maximum benefit of $210). Restrictions may apply.

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Differin® Lotion 0.1% and Differin® Gel 0.3% are indicated for the topical treatment of acne vulgaris in patients 12 years and older. Cutaneous irritation (erythema, scaling, dryness and/or stinging/burning) has been reported in clinical studies of these products. The majority of cases were mild to moderate in severity, occurred early in treatment and decreased thereafter. Other side effects that may occur from using Differin Lotion 0.1% and Differin Gel 0.3% include dry skin, skin discomfort, pruritus, desquamation and sunburn.

Concomitant use of potentially irritating products or overexposure to sunlight or sunlamps, extreme wind or cold, may increase the potential for irritation. Use of sunscreen and protective clothing over treated areas are recommended when exposure cannot be avoided. Do not use Differin Lotion 0.1% and Differin Gel 0.3% if you are allergic to adapalene or any of the other ingredients in the product. Talk to your doctor to learn more about Differin Lotion 0.1% and Differin Gel 0.3%.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.