Your face deserves a Differin® approach

“This is a massive game-changer if you have acne.”

New Differin Gel (adapalene 0.1%)

Here it is. New Differin Gel for clearing and preventing acne is the first and only FDA-approved, prescription-strength retinoid acne treatment available over the counter.
It’s time to do things Differin.


Meet the stars of your new skincare routine

Clear your acne and face the world with
renewed confidence.

New Differin Gel (adapalene 0.1%) packaging New Differin Gel (adapalene 0.1%) tube
Differin Gel (adapalene 0.1%)

Restores the tone and texture of your skin by clearing acne with the power of Rx.

Differin Balancing Cleanser packaging Differin Balancing Cleanser bottle
Differin Balancing Cleanser

Gently removes makeup and other impurities, even on sensitive skin.

Differin Balancing Moisturizer packaging Differin Balancing Moisturizer bottle
Differin Balancing Moisturizer

Perfectly pairs with Differin Gel for hydrated, healthy skin, with no greasy feel.


See the difference Differin can make

Week 0

Apply a thin layer of Differin Gel all over your face once every day, whether you have just a few spots or a full-on breakout. Working it into your daily skincare routine — and not skipping days — is important to allow the gel to do its job clearing and preventing acne.

Week 2

You may start to see a reduction in acne around the two-week mark, and some may even see results after one-week. Some dryness and irritation may occur — it’s normal and usually only lasts a few weeks. Use Differin Balancing Moisturizer to help with any dryness.

Week 12

This is what you’ve been waiting for. Acne is significantly reduced by week 12 (nearly a 60% reduction, according to clinical studies). Your skin is healthier, and you’re looking at a face you can feel great about. Keep Differin in your daily routine for continued improvement.

Simulation of actual clinical results

Before Differin Gel, a simulation of actual clinical results

Use a thin layer of Differin Gel once daily, all over your face – not just on acne spots

Differin Gel works both deep in the pores and on the skin’s surface

During use of Differin Gel (adapalene 0.1%), a simulation of actual clinical results

Acne spots begin to decrease

Any dryness and irritation usually subsides after about 4 weeks. Don’t let it stop you from getting to your best skin

If irritation becomes severe or overly bothersome, stop use and ask a doctor before continuing use

Differin Gel results, a simulation of actual clinical results

Acne is noticeably reduced, which leads to improvement of skin tone and texture

Continue to use Differin Gel daily to keep pores clear and help prevent future breakouts

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