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Learn more about Differin® Gel (adapalene 0.1%). 2018 Glamour Beauty Awards winner.

Treat and prevent your acne with the first FDA approved over-the-counter retinoid, Differin Gel. Click on the video to learn how to use Differin Gel in your daily routine to fight acne.

Learn more about Differin® Gel (adapalene 0.1%). 2018 Glamour Beauty Awards winner.
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Real people. Real results.

Take the 90 day #DifferinChallenge IRL. Check out @DifferinUS for real results from people just like you–and see what happens when you #DoThingsDifferin.

Differin real before and after acne treatment results - Example 0
Differin real before and after acne treatment results - Example 1
Differin real before and after acne treatment results - Example 2
Differin real before and after acne treatment results - Example 3
Differin real before and after acne treatment results - Example 4
Dr Adam Friedman Photo

A Dermatologist's Perspective

Dr. Adam Friedman, one of our go-to dermatologists, shares his thoughts on all things acne, retinoids and skin health. Look for his videos throughout the site to instantly see what he has to say.

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Meet the stars of your new skincare routine

Clear your acne and face the world with
renewed confidence.

Differin® Gel (adapalene 0.1%)

Restores the tone and texture of your skin by clearing acne with the power of Rx.

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Gentle Cleanser

Gently removes makeup and other impurities, even on sensitive skin.

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Oil Absorbing Moisturizer with SPF 30

Provides daily sun protection without clogging pores and soothes skin from the drying effects of some acne treatments.

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See the difference Differin can make

Week 0

Apply a thin layer of Differin® Gel all over your face once every day, whether you have just a few spots or a full-on breakout. Working it into your daily skincare routine — and not skipping days — is important to allow the gel to do its job clearing and preventing acne.

Week 2

You may start to see a reduction in acne around the two-week mark, and some may even see results after one-week. Some dryness and irritation may occur — it’s normal and usually only lasts a few weeks. Use a moisturizer like Differin Soothing Moisturizer.

Week 12

This is what you've been waiting for. Acne is significantly reduced by week 12 (up to 87% reduction, according to clinical studies). Your skin is healthier, and you’re looking at a face you can feel great about. Keep Differin in your daily routine for continued improvement.

Simulation of actual clinical results

Before Differin® Gel, a simulation of actual clinical results

Use a thin layer of Differin® Gel once daily, all over your face - not just on acne spots.

Differin® Gel works both deep in the pores and on the skin's surface.

During use of Differin® Gel (adapalene 0.1%), a simulation of actual clinical results

Acne spots begin to decrease.

Any dryness and irritation usually subsides after about 4 weeks. Don't let it stop you from getting to your best skin.

Switch to using every other day if you experience too much irritation when starting Differin® Gel. If irritation becomes severe or overly bothersome, stop use and ask a doctor before continuing use.

Differin® Gel results, a simulation of actual clinical results

Acne is noticeably reduced, which leads to improvement of skin tone and texture.

Continue to use Differin® Gel daily to keep pores clear and help prevent future breakouts.